Prameela began her acting career as a child artist in the 1960s, appearing in films like "Ambayyil" (1963) and "Ammayathu" (1965). She gained recognition for her performances in films like "Aparadhi" (1971) and "Pavangalum Padhathu" (1972). Her breakthrough role came with the 1975 film "Hachiko," which earned her critical acclaim and established her as a leading lady in Malayalam cinema.