Kanae's most notable work, "Nana," is a semi-autobiographical manga series that follows the lives of two women, both named Nana, as they navigate love, friendship, and identity in Tokyo. The series, which was published from 2005 to 2013, explores themes of womanhood, relationships, and the challenges of adulthood. "Nana" has been praised for its realistic portrayal of women's lives, its well-developed characters, and Kanae's beautiful artwork.