The movie is based on the classic 1930s-1940s film series of the same name. The story revolves around the adventures of three friends, Moe (Will Ferrell), Larry (Larry David), and Curly (Sean Hayes), who start a medical practice in a small town. The trio, known for their slapstick humor and silly antics, tries to make a name for themselves as doctors, but their unorthodox methods lead to chaos and hilarity.